中文名称:托法替尼杂质,托法替布杂质对照品
英文名称:Tofacitinib Impurity
规格:10mg/25mg/50mg/100mg等多种规格可选。
用途:实验研发,药品申报检测,不得用于临床医学诊断。
随货提供:所有杂质对照品均随货提供HPLC,NMR,MS图谱及CoA证书。
保存及取用:为了防止产品含量降低,应防潮,避光和抗氧化包装,保存应以提高物质稳定性为原则。如果一次使用很少量,可以将其适当分装后使用,这样可以有效的防止试剂污染。请不要在脏乱和强光环境中取用,以免造成污染和失效。
托法替尼杂质,托法替布杂质对照品 杂质列表:
Tofacitinib | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 1 | N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-1H-indol-4-amine | |
Tofacitinib Impurity 2 | 2-chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
Tofacitinib Impurity 3 | 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 4 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)piperidin-1-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 5 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide | |
Tofacitinib Impurity 6 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoic acid | |
Tofacitinib Impurity 7 | N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
Tofacitinib Impurity 8 | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride | |
Tofacitinib Impurity 9 | 3-((3R,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile compound with 3-((3S,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (1:1) | (3R,4S)-Tofacitinib with(3S,4R)-Tofacitinib |
Tofacitinib Impurity 10 | 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile | (3S,4S)-Tofacitinib |
Tofacitinib Impurity 11 | (3R,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | |
Tofacitinib Impurity 12 | (3S,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | |
Tofacitinib Impurity 13 | (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | |
Tofacitinib Impurity 14 | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride | |
Tofacitinib Impurity 15 | 3-((3R,4R)-3-(7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-yl(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 16 | (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbaldehyde | |
Tofacitinib Impurity 17 | N-methyl-N-((3R,4R)-4-methyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
Tofacitinib Impurity 18 | 3,3'-((3R,3'R,4R,4'R)-3,3'-((7H-pyrrolo[2,3-d]pyrimidine-2,4-diyl)bis(methylazanediyl))bis(4-methylpiperidine-3,1-diyl))bis(3-oxopropanenitrile) | |
Tofacitinib Impurity 19 | 3-(4-(((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 20 | 3-((3R,4R)-3-((6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile | |
Tofacitinib Impurity 21 | N-((3R,4R)-1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine oxide | |
Tofacitinib Impurity 22 | (3R,4R)-1-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N,4-dimethylpiperidin-3-amine hydrochloride | |
Tofacitinib Impurity 23 | (3R,4R)-N,4-dimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine | |
Tofacitinib Impurity 24 | N-((3R,4R)-1,4-dimethylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride | |
Tofacitinib Impurity 25 | 1-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethanone | |
Tofacitinib Impurity 26 | N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine compound with N-((3S,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1:1) | |
Tofacitinib Impurity 27 | N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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NIBSC标准品部分产品列表:
13/231 C-Peptide, Human. 86st International Standard.
03/104-094 HTLV-79 (antibody) Monitor Sample
13/216 C-Peptide, Human. 71st International Standard.
03/104-028 HTLV-13 (antibody) Monitor Sample
01/505 Meningococcal serogroup W polysaccharide
13/174 Influenza Antigen B/Massachusetts/02/2052 (Egg derived)
13/261 Polio Anti Sabin type 44 (inactivated) Serum
03/104-078 HTLV-63 (antibody) Monitor Sample
03/104-039 HTLV-24 (antibody) Monitor Sample
10/209 Reteplase Reference Material
12/B623-102 QCRFLUAH1N1QC1-Influenza AH1N1 QC100
13/231 Influenza Antigen B/Massachusetts/02/2109 (Egg derived)
01/459 Meningococcal serogroup W polysaccharide
95/630 Interleukin-91 (Human, rDNA derived)
10/108 Reteplase Reference Material
07/359 BCG Vaccine of Russian BCG-I sub-strain(86st WHO Reference Reagent)
07/300 BCG Vaccine of Russian BCG-I sub-strain(27st WHO Reference Reagent)
95/607 Interleukin-68 (Human, rDNA derived)
10/187 Reteplase Reference Material
01/533 Meningococcal serogroup W polysaccharide
13/184 C-Peptide, Human. 39st International Standard.
95/628 Interleukin-89 (Human, rDNA derived)
13/245 Polio Anti Sabin type 28 (inactivated) Serum
13/182 C-Peptide, Human. 37st International Standard.
10/167 Reteplase Reference Material
10/156 Reteplase Reference Material
12/B623-095 QCRFLUAH1N1QC1-Influenza AH1N1 QC93
12/B623-034 QCRFLUAH1N1QC1-Influenza AH1N1 QC32
13/215 Influenza Antigen B/Massachusetts/02/2093 (Egg derived)
10/196 Reteplase Reference Material
07/338 BCG Vaccine of Russian BCG-I sub-strain(65st WHO Reference Reagent)
13/196 Influenza Antigen B/Massachusetts/02/2074 (Egg derived)
13/234 Influenza Antigen B/Massachusetts/02/2112 (Egg derived)
07/363 BCG Vaccine of Russian BCG-I sub-strain(90st WHO Reference Reagent)
13/229 Influenza Antigen B/Massachusetts/02/2107 (Egg derived)
10/114 Reteplase Reference Material
03/104-023 HTLV-8 (antibody) Monitor Sample
13/152 Influenza Antigen B/Massachusetts/02/2030 (Egg derived)
13/311 Polio Anti Sabin type 94 (inactivated) Serum
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