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中文名称：阿法替尼杂质，达比加群酯杂质对照品标准品
英文名称：Afatinib Impurity，Dabigatran Impurity
规格：10mg/25mg/50mg/100mg等多种规格可选。
用途：实验研发，药品申报检测，不得用于临床医学诊断。
随货提供：所有杂质对照品均随货提供HPLC，NMR，MS图谱及CoA证书。
保存及取用：为了防止产品含量降低，应防潮，避光和抗氧化包装，保存应以提高物质稳定性为原则。如果一次使用很少量，可以将其适当分装后使用，这样可以有效的防止试剂污染。请不要在脏乱和强光环境中取用，以免造成污染和失效。
阿法替尼杂质，达比加群酯杂质对照品标准品 杂质列表：
| Afatinib | (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Afatinib Impurity 1 | (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine |
| Afatinib Impurity 2 | (S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine |
| Afatinib Impurity 3 | (R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Afatinib Impurity 4 | (S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Afatinib Impurity 5 | (S,E)-N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Afatinib Impurity 6 | (S,E)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide |
| Afatinib Impurity 7 | (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide |
| Afatinib Impurity 8 | (S,E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide |
| Afatinib Impurity 9 | (S,E)-4-(dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide |
| Afatinib Impurity 10 | (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide |
| Afatinib Impurity 11 | |
| Afatinib Impurity 12 | 1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one |
| Dabigatran | 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid |
| Dabigatran Impurity 1 | ethyl 3-(2-(iminomethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 2 | 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid |
| Dabigatran Impurity 3 | ethyl 3-(1-methyl-3-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydroquinoxaline-6-carboxamido)propanoate |
| Dabigatran Impurity 4 | methyl 3-(2-(hydroxymethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 5 | 3-(2-(chloromethyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid |
| Dabigatran Impurity 6 | diethyl 3,3'-((2,2'-(oxybis(methylene))bis(1-methyl-1H-benzo[d]imidazole-5,5'-carbonyl))bis(pyridin-2-ylazanediyl))dipropanoate |
| Dabigatran Impurity 7 | hexyl (imino(4-(((1-methyl-5-(pyridin-2-ylcarbamoyl)-1H-benzo[d]imidazol-2-yl)methyl)amino)phenyl)methyl)carbamate |
| Dabigatran Impurity 8 | (Z)-3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoic acid |
| Dabigatran Impurity 9 | ethyl 3-(2-(((4-(((hexyloxy)carbonyl)carbamoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 10 | (Z)-ethyl 3-(2-(((4-(N'-((hexan-2-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 11 | (Z)-ethyl 3-(2-(((4-(N'-((hexan-3-yloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 12 | ethyl 3-(1,2-dimethyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 13 | ethyl 3-(1-methyl-2-oxo-N-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 14 | (Z)-ethyl 2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-1H-benzo[d]imidazole-5-carboxylate |
| Dabigatran Impurity 15 | ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 16 | ethyl 3-(2-(((4-(ethoxy(imino)methyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride |
| Dabigatran Impurity 17 | (Z)-methyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 18 | (Z)-hexyl (amino(4-(((5-((3-amino-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)phenyl)methylene)carbamate |
| Dabigatran Impurity 19 | ethyl 3-(2-(((4-carbamoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate |
| Dabigatran Impurity 20 | ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride |
| Dabigatran Impurity 21 | ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate |
| Dabigatran Impurity 22 | ethyl 3-(3-(2-((4-cyanophenyl)amino)acetamido)-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate |
若杂质列表中未有您需要的杂质，欢迎来电或在线详询，产品库时常会有更新，另外，我司有专业研发团队，可提供部分杂质定制服务，以最大可能的满足您对杂质对照品的选购需求。
阿法替尼杂质，达比加群酯杂质对照品标准品 订购方式：
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阿法替尼杂质，达比加群酯杂质对照品标准品 作用机理：
阿法替尼是一种口服药物，是表皮生长因子受体(EGFR)和人表皮受体2(HER2)酪氨酸激酶的不可逆抑制剂。Ⅱb/Ⅲ期随机研究表明，与安慰剂+最佳支持治疗相比，阿法替尼+最佳支持治疗治疗既往一二线化疗及EGFR-TKI治疗失败的非小细胞肺癌患者，未改善患者总生存，但显著改善了无进展生存期，提高了ORR和8周疾病控制率。另一项研究（LUX-LUNG2）结果显示，伴有常见EGFR突变类型的大多数（61%）患者接受阿法替尼治疗后，肿瘤显著缩小、肿瘤进展时间较晚、生存期较长。这些结果初步证实阿法替尼是比较有前途的靶向药物。
阿法替尼为不可逆转的ErbB家族阻断剂，能抑压信息传导和阻隔与癌细胞生长和分裂相关的主要通道。由于通过ErbB家族信息传导机制可由多个同二聚体跟异二聚体引发，所以同时抑制多个ErbB家族成员(如 EGFR, HER2, ErbB3 及 ErbB4)，能较有效地中断下游信息传导。
达比加群酯是最前沿的新一代口服抗凝药物直接凝血酶抑制剂(DTIs)，用于预防非瓣膜性房颤患者的卒中和全身性栓塞。达比加群酯可提供有效的、可预测的、稳定的抗凝效果，同时较少发生药物相互作用，无药物食物相互作用，无需常规进行凝血功能监测或剂量调整。
阿法替尼杂质，达比加群酯杂质对照品标准品 深圳远扬专注医药标准品，杂质对照品，更多产品，欢迎选购（篇幅有限，只列举了一小部分，更多更全，请来电详询）：
杂质对照品部分产品列表：
法罗培南杂质，氯丁替诺杂质，溴麦角环肽杂质，吉格列汀杂质，替米沙坦杂质，番泻苷ABCD，维兰特罗杂质，非那沙星杂质，卡巴拉汀杂质，福沙匹坦异构体，艾沙康唑杂质，头孢泊肟酯杂质，噻吗洛尔杂质，盐酸拓扑替康杂质，利培酮杂质，富马酸福莫特罗杂质，雷莫拉宁杂质，碘帕醇杂质，卡巴他赛杂质，克林霉素杂质，依普利酮杂质，盐酸伊立替康杂质，纳曲酮杂质，喹法米特杂质，维罗非尼杂质，阿德福韦酯杂质，伊伐布雷定杂质，盐酸奥洛他定杂质，CO-1686杂质，盐酸米诺环素杂质，缬沙坦杂质，特拉匹韦杂质，卡博替尼杂质，普萘洛尔杂质，氨曲南杂质，替普瑞酮杂质，佐米曲普坦杂质，盐酸多塞平杂质，豆甾醇杂质，依普沙坦杂质，帕利哌酮杂质，多柔比星杂质，雷马曲班杂质，哌唑嗪杂质，达比加群酯杂质，恩杂鲁胺杂质，托法替布杂质，达泊西汀杂质，盐酸环苯扎林杂质，溴隐亭杂质，沙丁胺醇杂质，盐酸氯哌斯丁杂质，阿扎胞苷杂质，阿立哌唑杂质，美普他酚杂质，度鲁特韦杂质，莫匹罗星杂质，蝶酸杂质
